Scientists make breakthrough in new drug for heart attack

Scientists at the MDI Biological Laboratory and Novo Biosciences have identified a drug to restore heart muscle function following a heart attack.

Their research on the role of MSI-1436 in regenerating heart muscle tissue in zebrafish and mice was described in a paper in the peer-review journal, npj Regenerative Medicine.

Cardiovascular disease is the world’s leading killer, taking the lives of 17.5 million people annually, according to the World Health Organization, and disabling millions more. Currently, no drug exists to restore heart muscle function after a heart attack.

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“The potential impact of MSI-1436 is enormous,” MDI Biological Laboratory scientist Viravuth P. Yin, Ph.D., one of the paper’s authors, said. “If it shows similar results in humans, it will be a game-changer for patients who suffer a heart attack and/or are living with heart disease.”

The institution is seeking to move the drug into human clinical trials through a spinoff company, Novo Biosciences. The next step is to test the drug in pigs, the animal whose heart most closely resembles that of humans.

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